MK-677 (Ibutamoren)
Also known as Ibutamoren, Ibutamoren Mesylate, Nutrobal, MK-0677
An orally active, non-peptide ghrelin receptor agonist that stimulates sustained growth hormone and IGF-1 release. A convenient oral alternative to injectable GH secretagogues, popular for sleep, recovery, and lean-mass support.
How it works
Mimics ghrelin at the GHS-R1a receptor in the pituitary and hypothalamus, amplifying natural pulsatile GH release without suppressing the GH axis.
Benefits
- Raises GH and IGF-1
- Improves sleep depth
- Supports muscle mass and recovery
- Increases appetite
- May improve skin, hair, and bone density
Dosing
10–25 mg · Once daily (oral)
Typically 10-25 mg/day, often before bed (can aid sleep) or in the AM if it disrupts sleep. Effects build over weeks.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Common stacks
Reported side effects
- Increased appetite
- Water retention
- Lethargy or grogginess
- Numbness and tingling
- Raised fasting glucose / insulin resistance
- Vivid dreams
Who it’s for
Those wanting GH-axis support without injections. Caution in diabetics (insulin sensitivity) and anyone sensitive to water retention or appetite increase.
Track MK-677 (Ibutamoren) in Helix
Dose reminders, reconstitution math, vial tracking, and AI guidance — free on iOS.
Download free