TB-500
Also known as Thymosin Beta-4, Tβ4
TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide present in almost every cell in the body. It's the most systemic healing peptide — unlike BPC-157 which is more localized, TB-500 travels throughout the body to repair damage wherever it finds it.
How it works
Sequesters actin monomers, modulating actin dynamics critical for cell migration and tissue remodeling. Upregulates anti-inflammatory cytokines and promotes endothelial cell migration via integrin-linked kinase pathway.
Benefits
- Systemic tissue repair — heals injuries throughout the body
- Reduces chronic inflammation
- Improves flexibility and range of motion
- Accelerates muscle fiber repair
- Hair growth stimulation
- Cardiac tissue repair in animal studies
- Angiogenesis promotion
Dosing
2.5–7.5 mg · 1–2x per week (loading), then 1x per week or biweekly
Loading phase: 2–7.5mg twice weekly for 4–6 weeks. Maintenance: 2–2.5mg weekly or biweekly.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
5mg vial with 2mL BAC water = 2.5mg/mL
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Head rush post-injection
- Fatigue
- Generally well tolerated
- Rare: cancer concern flag in theory (promotes cell migration) — largely theoretical
Who it’s for
Athletes with chronic or multiple injuries, those wanting systemic recovery support, or older adults with general tissue maintenance goals. Excellent stacked with BPC-157.
Track TB-500 in Helix
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