L-Glutathione (Injectable)
Also known as GSH, Glutathione, reduced glutathione, L-GSH
L-Glutathione is the body's master antioxidant — a tripeptide (Glu-Cys-Gly) present in virtually every cell. Injectable glutathione bypasses gut degradation to deliver significantly higher plasma levels than oral supplementation. It neutralizes reactive oxygen species, recycles other antioxidants (vitamins C and E), supports liver detoxification, and is central to mitochondrial health. Levels decline substantially with age and stress.
How it works
Functions as the primary intracellular antioxidant. Donates electrons to neutralize reactive oxygen species. Acts as a cofactor for glutathione peroxidase and glutathione S-transferase enzymes. Regenerates oxidized ascorbate (vitamin C). Binds and facilitates excretion of heavy metals and xenobiotics via mercapturic acid pathway.
Benefits
- Powerful systemic antioxidant — neutralizes free radicals
- Liver detoxification support (Phase II conjugation)
- Skin brightening and hyperpigmentation reduction
- Immune system enhancement
- Mitochondrial protection and energy production support
- Recycles vitamins C and E
- Heavy metal chelation support
- Reduces oxidative stress in chronic disease
- Neurological protection
Dosing
600–1200 mg · 2–3x per week
IV push: 600–1200mg in saline. IM: 200–600mg. SubQ less common but used. Skin brightening protocols often use 600–1200mg IV 2–3x/week. Maintenance: weekly.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Typically comes lyophilized. Reconstitute with sterile water or saline. Do not mix with vitamin B12 (inactivates). Use immediately after reconstitution.
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Generally very safe
- Rare allergic reactions (anaphylaxis — have epinephrine on hand for IV)
- Zinc depletion with long-term high-dose use
- May temporarily lower blood pressure
Who it’s for
Anyone seeking antioxidant support, skin brightening, liver health, or anti-aging. Particularly valuable for those with high oxidative stress, toxin exposure, or chronic illness. Beginner-friendly.
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