LL-37
Also known as Cathelicidin, hCAP18/LL-37
LL-37 is a human host defense peptide — part of the innate immune system. It has potent antimicrobial, antiviral, and wound-healing properties. It's gaining attention for chronic infections, biofilm disruption, and skin conditions like acne and rosacea.
How it works
Amphipathic helix that disrupts bacterial membrane integrity. Modulates TLR signaling to balance pro- and anti-inflammatory responses. Promotes epithelial cell migration and angiogenesis.
Benefits
- Potent antimicrobial — kills bacteria, viruses, and fungi
- Disrupts bacterial biofilms (including drug-resistant strains)
- Accelerates wound healing
- Anti-inflammatory immune modulation
- Skin healing — acne, rosacea, psoriasis applications
- Antiviral activity
Dosing
100–500 mcg · Daily or every other day
Can be injected SubQ for systemic effect or applied topically for skin conditions.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Standard reconstitution
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Injection site pain (LL-37 is known to cause stinging)
- Potential pro-inflammatory at high doses
- Limited human data
Who it’s for
Those with chronic infections, wounds that won't heal, or skin conditions. Advanced users — dose-finding is less established than other peptides.
Track LL-37 in Helix
Dose reminders, reconstitution math, vial tracking, and AI guidance — free on iOS.
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