Dihexa
Also known as PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Dihexa is an extremely potent nootropic peptide — reportedly 10 million times more potent than BDNF in promoting synaptogenesis. It promotes the formation of new synaptic connections and is being studied for Alzheimer's and cognitive decline. Used with caution due to potency.
How it works
Binds and activates HGF/MET receptor system, promoting angiogenesis and synaptogenesis in the brain. Activates BDNF signaling pathways at extreme potency vs exogenous BDNF.
Benefits
- Extremely potent synaptogenesis (new synapse formation)
- Cognitive enhancement — memory, learning, processing
- Studied for Alzheimer's and cognitive decline treatment
- Long-lasting effects with short dosing cycles
- Neuroprotective
Dosing
2–10 mg · Every few days to weekly
Applied transdermally (most common — DMSO carrier) or SubQ. Due to extreme potency, dose infrequently. Effects build over time.
Ranges reflect commonly cited research protocols, not a prescription. Dose with a licensed provider.
Reconstitution
Often dissolved in DMSO for transdermal application
Helix’s free reconstitution calculator gives you the exact draw volume → get the app
Common stacks
Reported side effects
- Unknown long-term effects
- Potentially promotes unwanted cell growth (theoretical cancer concern at very high doses)
- Start very low
Who it’s for
Advanced users only. Cognitive performance optimization, neurological recovery, or prevention of cognitive decline. Start with very low doses due to extreme potency.
Track Dihexa in Helix
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